Study of Reserves After Traumatic Brain Injury

Sheba Medical Center240 enrolled

Overview

It is hypothesized that the long-term results of rehabilitation and subsequent aging after Brain Trauma depend on brain's premorbid anatomical (structural) and functional (cognitive, emotional) reserves. The purpose of this study are: 1. to determine whether such reserves exist. 2. to study their convergent and discriminant validity. 3. to study their characteristics.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

240

Conditions

Traumatic Brain Injury

Interventions

Brain MRIDEVICE

Brain MRI

MRIDEVICE

Physical examination Neuropsychological testing Questionnaires

Eligibility

Sex: ALLMin age: 19 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Moderate-Severe Traumatic Brain Injury according to at least 1 the following: * Duration of loss of consciousness (LOC) - more then 1/2 hour * Glasgow Coma Scale (GCS) - less then 13 * Post Traumatic Amnesia (PTA) - more then 24 hours. * At least 1 year after the injury. Exclusion Criteria: * Mild Traumatic Brain Injury * the present state of Post Traumatic Amnesia * dementia * the age less than 18 years on the moment of injury * less than 1 year since the injury * incapacity of the patient to cooperate in the study (incapacity of any source including physical, mental, and language problems) * premorbid diagnosis of Mental Retardation

Locations (1)

Sheba Tel Hashomer Medical Center

Ramat Gan, Israel

Outcomes

Primary Outcomes

Neuropsychological battery

Time frame: neuropsychological baterry for every participant will be performed during 3-4 meetings. An expected average for complete neuropsychological assessment is about 8 weeks

Data from ClinicalTrials.gov

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