Brain Functional Connectivity Changes Following Cognitive Rehabilitation in Multiple Sclerosis: an fMRI Study

Sina Hospital, Iran45 enrolled

Overview

This trial seeks to investigate brain network changes following cognitive rehabilitation in MS patients. The investigators hypothesize that rehabilitation interventions improve connectivity in the brain.Novel Magnetic Resonance Imaging technique is performed to investigate changes in brain plasticity.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

SINGLE

Enrollment

Conditions

MS (Multiple Sclerosis)

Interventions

Cog RehabBEHAVIORAL

Cognitive rehab for MS patients

Eligibility

Sex: ALLMin age: 18 YearsMax age: 54 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Definitive MS diagnosis * Right handedness * EDSS 0-4 * No relapse in past 6 weeks * Willing to consent and participate in the study Exclusion Criteria: * Pregnancy * Left handedness * Neurologic or psychiatric disorder other than MS

Locations (1)

Sina Hospital

Tehran, Tehran Province, Iran

Outcomes

Primary Outcomes

functional connectivity

Changes in correlation of brain activity in different regions of brain as assessed by Blood Oxygenation Level Dependent (BOLD) signal

Time frame: 0, 2nd, 4th Month

Data from ClinicalTrials.gov

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