The purpose of this study is to investigate the association between GRK4 polymorphisms and essential hypertension in southwestern Han Chinese and test whether these polymorphisms were associated with the changes in blood pressure in patients with essential hypertension treated with angiotensin II Type antagonist candesartan.
All antihypertensive agents were withdrawn before the start of a 4-6 week, single-blind, after which the patients received candesartan 10 mg or 20mg once daily as monotherapy in a single-blind fashion. The doses were doubled after 1 weeks if DBP was ≥ 90 mmHg.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
SINGLE
Enrollment
500
To investigate the response to candesartan among southwestern Han Chinese with essential hypertrension
Department of Cardiology, Daping Hospital, The Third Military Medical University
Chongqing, China
RECRUITINGThe subjects with GRK4 varirants may exert different response during 4 weeks of treatment with candesartan in patients with essential hypertension
Time frame: two years
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