A Clinical Study for Evaluating the Safety of Excessive Consumption of a Plant Sterol-enriched Yoghurt Drink

Inclusion Criteria: * male/female subjects, * aged 20-65 years old, * triglycerides (TG) levels under 400 mg/dL, * total cholesterol plasma level under 240 mg/dL (with half the subjects at entry under 200 mg/dL), * LDL-cholesterol plasma level under 160 mg/dL (with half the subjects at entry under 120 mg/dL), * non diabetic and non hypertensive, * accepting to follow the dietary recommendations advisable for hypercholesterolemic patient (Japan Atherosclerosis Society guidelines), * effective contraceptive methods used for female subjects, * having given written consent to take part in the study Exclusion Criteria: * subjects with sitosterolemia, * subjects with 200 ml of blood taken within the past month or 400 ml or more within the past 3 months, * taking any hypocholesterolemic treatment, * presenting known allergy or hypersensitivity to plant sterols, * dairy products and lactose, subject with heavy alcohol intake (\> 60g/day), * receiving systemic treatment or topical treatment likely to interfere with evaluation of the study parameters, * subjects receiving a transplant or under immunosuppressor treatment, * receiving treatment for any serious pathology. * for female subject: * pregnancy, * breast feeding or * intention to be pregnant during the study