The Effect of Recruitment Maneuver With Protective Ventilation During Thoracic Surgery

Seoul National University Hospital60 enrolled

Overview

The purpose of this study is to determine if a recruitment maneuver combined with protective ventilatory strategy could reduce the pulmonary and systemic inflammatory responses to one-lung ventilation during thoracic surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Mechanical Ventilation Complication Thoracic Surgery Inflammation

Interventions

protective ventilationPROCEDURE

low tidal volume and PEEP

Recruitment maneuver combined with protective ventilationPROCEDURE

Low tidal volume, PEEP and recruitment maneuver

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 20 Years and older * Patients undergoing thoracic surgery Exclusion Criteria: * Emergency surgery * Heart failure * Pulmonary hypertension * Forced vital capacity or forced expiratory volume in 1 sec \< 50% of the predicted values * Coagulation disorder * Pulmonary or extrapulmonary infections * History of treatment with steroid in 3 months before surgery * History of recurrent pneumothorax * History of lung resection surgery

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Levels of IL-8, TNFa in the bronchoalveolar lavage

Time frame: up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery

Secondary Outcomes

Levels of IL-1, IL-6, IL-10 in the bronchoalveolar lavage

Time frame: up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery

plasmatic concentration of inflammatory mediators IL-1, IL-6, IL-8, IL-10, TNFa

Time frame: up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery

oxygenation

Changes in PaO2/FIO2 ratio

Time frame: 1 hour after extubation

Chest-X ray

Time frame: 7 days after surgery

Data from ClinicalTrials.gov

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