The Safe Effective Light Dose of Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Yeungnam University College of Medicine45 enrolled

Overview

To find the safe effective lowest light dose for photodynamic therapy (PDT). in the treatment of central serous chorioretinopathy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Central Serous Chorioretinopathy

Interventions

Photodynamic therapyPROCEDURE

Photodynamic therapy is performed using verteporfin. Full dose of verteporfin is infused for 10 minutes, followed by laser delivery at 15 minutes from the start of infusion. Different light dose of PDT is applied to the patients at 50%, 40% and 30% of the full energy based on TAP study. The area of irradiation is set to the abnormal choroidal vascular hyperpermeability on ICGA corresponding to the leaking area on FA.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Idiopathic detachment of the neurosensory retina with a focal leak at the level of the RPE with FA 2. Presence of SRF and/or serous pigment epithelial detachment on optical coherence tomography (OCT) 3. Presence of abnormal dilated choroidal vasculature in ICGA 4. Patients with symptomatic CSC of at least 3 months duration Exclusion Criteria: 1. Patients who received any previous treatment, including PDT or focal thermal laser photocoagulation for CSC, or who had evidence of CNV, PCV, or other maculopathy on clinical examination, FA, or ICGA 2. Patients receiving exogenous corticosteroid treatment 3. Patients with systemic diseases such as Cushing's disease or renal diseases 4. Pregnant patients

Locations (1)

Yeungnam University College of Medicine

Daegu, South Korea

RECRUITING

Outcomes

Primary Outcomes

Changes of best corrected visual acuity

Changes of best corrected visual acuity at baseline and 1, 3, 6 month after PDT

Time frame: 6 month

Secondary Outcomes

Change of central retinal thickness, success rate, recurrence rate, and complications

Change of the central retinal thickness on optical coherence tomography (OCT)are compared at baseline at 1, 3, and 6 months after PDT. Additionally, success rate, recurrence rate, and complications between three groups are evaluated during 6 months.

Time frame: 6 months

Central Contacts

Min Sagong

CONTACT

82-53-620-4191 msagong@ynu.ac.kr

Data from ClinicalTrials.gov

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