Effects of Denosumab on Periprosthetic Bone After Total Hip Arthroplasty

Inclusion Criteria: 1. male or female patient 35-65 years of age with an unilateral OAH requiring a THA and a healthy contralateral hip 2. body weight ≤110 kg or body mass index (BMI) ≤35 kg/m2 3. living in the Uppsala County 4. the eligible patients should have been given oral information, a written Patient Information and signed an Informed Consent Exclusion Criteria: 1. on or previously have had bone-specific treatment, e.g. bisphosphonates, raloxifene, parathyroid hormone, strontium ranelate, during the last five years 2. patients on systemical corticosteroid for more than 3 months should not be considered 3. patients with diagnosed malignant disease during the last five years or known to have metastasis from malignant disease should be excluded 4. patients with compromised general conditions and an American Society of Anesthesiologists, ASA-score \>31 should not be regarded eligible 5. patients with known drug or alcohol abuse or regarded as socially dysfunctional, as judged by the investigator, should not be considered for the study 6. pregnant women or women planning for pregnancy or fertile women (premenopausal) without contraceptives should not be accepted for the study 7. patients that have been exposed frequently and/or have had large irradiation doses, as judged by the investigator, must not be included in the study. 8. enrolled in either another investigational drug study, in another investigational device study, or in another investigational study of an approved drug within 30 days prior to Visit 1 of the current study 9. any condition or laboratory findings which in the opinion of the Investigator makes the patient unsuitable for inclusion (for example claustrophobia)