Evaluation of the Metabolic Effects of LCZ696 and Amlodipine in Obese Hypertensive Subjects

Inclusion Criteria: * Written informed consent must be obtained before any study assessment is performed. * Males and females of non-childbearing potential ≥ 18 years of age. * Subjects with mild to moderate essential hypertension, * Untreated subjects must have a mean seated SBP (msSBP) ≥ 130 mmHg and \< 180 mmHg at screening. * Pre-treated subjects must have a msSBP ≤ 160 mmHg at screening and \< 180 mmHg at the end of the washout period. * Waist circumference ≥ 102 cm (men) and ≥ 88 cm (women); Exclusion criteria: * Use of other investigational drugs at the time of enrollment, or within 30 days or 5 half-lives of enrollment, whichever is longer; or longer if required by local regulations. * History of angioedema, drug-related or otherwise * History of hypersensitivity to LCZ696, amlodipine, or drugs of similar chemical classes. * Severe hypertension (grade 3 of WHO classification; msDBP ≥100 mmHg and/or msSBP ≥ 180 mmHg) at screening or at the end of the washout period. * Type 1 or Type 2 diabetes mellitus. * Dyslipidemia requiring pharmacological therapy with a fibrate or nicotinic acid. * Concomitant use of anti-hypertensives, anti-diabetics, or drugs with effects on glucose or lipid metabolism for the duration of the study. Other protocol defined inclusion/exclusion criteria may apply