Examination of ADMA (Asymmetric-Dimethylarginine)-serum level and DDAH II (Dimethylarginine Dimethylaminohydrolase)- Polymorphism in patients with severe Sepsis and septic shock as prognostic value. This study looks into ADMA as a good prognostic factor for sepsis. Further more the dependency of the ADMA level to the DDAH II polymorphisms is reviewed this study.
Secondary targets are the mortality (28 days ICU), the length of hospitalisation in ICU and peripheral station, the severity of the illness (SAPS II score), the SOFA-score values in the progress and the procalcitonin values in the progress
Study Type
OBSERVATIONAL
Enrollment
120
Universitätskrankenhaus Hamburg Eppendorf
Hamburg, Germany
ADMA serum levels
measuring of ADMA serum levels on day 1, 3, 7
Time frame: 7 days
28 day mortality
Time frame: 28 day
hospitalisation (ICU and peripheral)
Time frame: 28 days
severity of illness
Time frame: 28 days
DDAH Ii polymorphism
Time frame: 28 days
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