Leuven Growing Into Deficit Follow-up Study

KU Leuven172 enrolled

Overview

The key objective of the Leuven growing-into-deficit (GID) follow-up-study is to test the hypothesis that children with a congenital heart disease (CHD) show more neurocognitive impairment at the second follow-up at 7 years old than at the first follow-up at the age of 4, compared to healthy controls.

Study Type

OBSERVATIONAL

Enrollment

172

Conditions

Heart Defects, Congenital Critical Illness Mental Processes Child

Eligibility

Sex: ALLMin age: 84 MonthsMax age: 89 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Seven-year-old children with CHD and healthy control children who were four years old when they participated in Paediatric ICU follow-up study (i.e. first follow-up time point) (Neurocognitive development of children four years after critical illness and treatment with tight glucose control, Clinical Trials # NCT00214916). The children of the CHD-group underwent cardiac surgery as infants (=\<1year). Exclusion Criteria: * Genetic syndromes (Down, 22q11del), known to result in neurocognitive impairment * IQ \< 70 * Lack of baseline neurocognitive measurements during first follow-up * Date of birth before February 2005

Locations (1)

Dept Intensive Care Medicine

Leuven, Vlaams Brabant, Belgium

Outcomes

Primary Outcomes

reaction time (RT) and error rates of inhibitory control (Response Organization Objects, ROO) (Amsterdam Neuropsychological Tasks, ANT)