Pomalidomide (POM) in Combination With Low Dose Dexamethasone (LD-Dex) in Patients With Relapsed or Refractory Multiple Myeloma

Inclusion Criteria: 1. Must have documented diagnosis of relapsed or relapsed/refractory multiple myeloma and have measurable disease (serum or urine M-protein) 2. Age ≥ 18 years 3. Must have had at least ≥ 2 prior anti-myeloma therapies 4. Must have received at least 2 consecutive cycles of both lenalidomide and bortezomib, either alone or in combination 5. Must have failed treatment with the last lenalidomide-containing regimen and the last bortezomib-containing regimen 6. Must have documented disease progression during or after the last antimyeloma regimen 7. Females of childbearing potential (FCBP) must agree to utilize two reliable forms of contraception simultaneously or practice complete abstinence from heterosexual contact for at least 28 days before starting drug, while participating in the study and for at least 28 days after study treatment discontinuation. 8. Males must agree to use a latex condom during sexual contact with FCBP while participating in the study and for 28 days following discontinuation from study treatment. Exclusion Criteria: 1. Peripheral Neuropathy ≥ Grade 2 2. Non-secretory multiple myeloma 3. Previous therapy with pomalidomide 4. Use of any investigational agents within 28 days or 5 half lives (whichever is longer) of initiating study treatment 5. Subjects with conditions requiring chronic steroid or immunosuppressive treatment. 6. Hypersensitivity to thalidomide, lenalidomide or dexamethasone 7. Known Human Immunodeficiency Virus positive, active or chronic Hepatitis A, B or C 8. Pregnant or breastfeeding females 9. Unacceptable hematological or biochemical laboratory abnormalities