Comparing PI-Based to a nNRTI-based ART for Clearance of Plasmodium Falciparum Parasitemia in HIV-Infected

Inclusion Criteria: * HIV-1 infection * CD4+ count \> 200 and \< 500 cells/mm\^3 obtained within 30 days prior to study entry at a DAIDS-approved laboratory. * Pf SCP confirmed in a laboratory approved to conduct parasitemia microscopy. Note: Pf SCP defined as meeting all three of the following criteria within 72 hours prior to study entry: 1. Microscopy confirmed parasitemia (see section 6.3.6 and the A5297 Manual of Procedures \[MOPS\]) 2. An oral temperature \< 37.5°C. 3. The absence of Grade 2 or greater signs or symptoms thought to be related to clinical malaria including: 1. headache 2. malaise or fatigue 3. abdominal discomfort 4. muscle or joint pain 5. fever 6. chills 7. perspiration 8. anorexia 9. vomiting 10. other signs or symptoms thought to be related to clinical malaria * Certain laboratory values obtained within 14 days prior to study entry, as detailed in section 4.1.4 of the protocol. * Hepatitis B surface antigen (HBsAg) negative within 30 days prior to entry. * Female study volunteers of reproductive potential have a negative serum or urine pregnancy test performed within 72 hours prior to entry. * All study volunteers agree not to participate in a conception process (eg, active attempt to become pregnant or to impregnate, sperm donation, in vitro fertilization) for study duration. If participating in sexual activity that could lead to pregnancy, must agree to use two reliable forms of contraceptive simultaneously while receiving protocol-specified medications. One form of contraceptive must be a barrier method if a participant receives EFV. Participants must agree to continue the use of two contraceptives for 6 months after stopping EFV and 6 weeks after stopping all other protocol-specified medications. * Study volunteers who are not of reproductive potential are eligible without requiring the use of a contraceptive. * Ability and willingness of participant or legal guardian/representative to provide informed consent. * Willing and able to return to the clinic twice to three times a day for study visits. Exclusion Criteria: Step 1: Exclusion Criteria * Previous history or current use of ART. * Single dose NVP or dual therapies used for Prevention of mother-to-child transmission (PMTCT) within 2 years prior to entry. * Use of any medication with antimalarial activity, including TMP/SMX (see list of prohibited medications in the A5297 Manual of Procedures (MOPS)), within 14 days prior to study entry. * Confirmed or clinically suspected OIs (including but not limited to tuberculosis, clinical malaria, PCP), or other pulmonary or gastrointestinal infections for which potential participants did not complete treatment more than 30 days prior to enrollment or have signs and symptoms during screening. * Breastfeeding. * Known allergy/sensitivity or any hypersensitivity to components of study drugs or their formulation. * Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements. * Serious illness requiring systemic treatment and/or hospitalization within 30 days prior to entry. * Results suggestive of active pulmonary disease from a chest x-ray performed within 30 days prior to study entry.