Performance-based Reinforcement to Enhance Cognitive Remediation Therapy

Yale University40 enrolled

Overview

The purpose of this study is to investigate whether monetary reinforcement for performance will enhance the effects of cognitive remediation therapy for substance users seeking treatment at an outpatient facility.

Forty individuals seeking treatment for an alcohol or cocaine use disorder at the Substance Abuse Treatment Unit (SATU) will be randomized to receive cognitive remediation therapy with or without additional compensation based on performance. Participants will use the computerized cognitive remediation program (PSSCogRehab 2012) three times per week for four weeks. The primary outcome measure will be an improved performance on the computerized tasks, with secondary outcomes of changes in cognitive functioning (e.g., attention, concentration, memory) as measured by neuropsychological tests between baseline and post-treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Interventions

Cognitive Remediation Therapy - StandardBEHAVIORAL

Computerized cognitive remediation therapy provided three times per week for four weeks

Cognitive Remediation Therapy plus Contingency ManagementBEHAVIORAL

Standard cognitive remediation therapy plus monetary incentives based on performance provided three times per week for four weeks.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 to 60 years old * Primary Alcohol and/or Cocaine Abuse/Dependence Diagnosis * Abstinence from all drugs/alcohol for 30 days * Mild cognitive impairment * Sufficiently stable and plan to commit to 4 weeks of outpatient treatment * Fluent in English and 6th grade reading ability Exclusion Criteria: * Severe cognitive impairment indicative of dementia * Untreated bipolar or psychotic disorder * Have current legal case pending such that incarceration during 4-week study is likely

Locations (1)

Substance Abuse Treatment Unit

New Haven, Connecticut, United States

Outcomes

Primary Outcomes

Improvement in performance scores on computerized cognitive remediation tasks

Performance scores on various computerized cognitive remediation tasks will be measured repeatedly during the 4 week study. These scores include "time to completion", "number of errors", "number of words correctly recalled", and "percentage of task completed"

Time frame: 4 weeks

Secondary Outcomes

Improved cognitive function on neuropsychological tests

Change in cognitive function between baseline and post-treatment will be measured by performance on neuropsychological tests, such as Trail Making Test A \& B, Wisconsin Card Sort Test, Digit Symbol Test from WAIS-IV, and the Continuous Performance Test-II (CPT-II).

Time frame: 4 weeks

Data from ClinicalTrials.gov

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