The aims of this study are to determine whether antibiotics administered routinely in women presenting with premature rupture of membranes later than the 37+0 weeks of gestation can alter the rate of maternal and neonatal infection and to compare these rates between prompt (\< 12 hour) and delayed (≥ 12 hour) induction in the group of patients not submitted to antibiotic prophylaxis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
161
ampicillin 1 g every six hours and gentamicin 240 mg every day intravenously
Hospital Santa Maria
Lisbon, Portugal
neonatal infection rate
neonatal infection rate includes early onset sepsis, meningitis and pneumonia
Time frame: participants will be followed for the duration of hospital stay, an expected average of 3 days
maternal infection rate
maternal infection rate includes chorioamnionitis or puerperal endometritis
Time frame: participants will be followed for the duration of hospital stay, an expected average of 3 days
comparison of the infection rates between prompt and delayed induction
rate of maternal and neonatal infection between prompt (\<12h) and delayed induction (≥12h) in the group of patients not submitted to antibiotic prophylaxis
Time frame: participants will be followed for the duration of hospital stay, an expected average of 3 days
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