Zinc Absorption From Biofortified Rice

Swiss Federal Institute of Technology16 enrolled

Overview

One of the newest strategies to combat micronutrient deficiencies is the biofortification of staple foods, where higher levels of minerals are obtained through breeding of staple crops. The aim of this study is to evaluate zinc absorption from a rice biofortified with zinc when compared with a control rice fortified with zinc just before consumption.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

Zinc biofortified riceOTHER

1.12 mg zinc per meal

Rice extrinsically fortified with zincOTHER

1.12 mg zinc per meal

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female of 18 to 45 years old * Body Mass Index in the range of 19 to 25 * No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study Exclusion Criteria: * Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement) * Long-term medication during the whole study (except for contraceptives) * Pregnancy * Lactation * Intention to become pregnant during the course of the study * Lack of safe contraception * Consumption of mineral and vitamin supplements within 2 weeks prior to 1st - Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study

Locations (1)

ETH Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

Fractional absorption of zinc

Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.

Time frame: 33 days

Data from ClinicalTrials.gov

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