Trends of Morbidity and Mortality Among Thai HIV-infected and HIV-uninfected Patients: a Five-year Prospective Cohort Study

Thai Red Cross AIDS Research Centre816 enrolled

Overview

1. To describe the morbidity and clinical characteristics among HIV-infected patients and HIV-uninfected patients. 2. To identify the risk factors for the complication or morbidity among HIV-infected patients and HIV-uninfected patients. 3. To describe the mortality among HIV-infected patients and HIV-uninfected patients. 4. To identify the risk factors for the cause of death among HIV-infected and HIV-uninfected patients.

The information obtained from this study would be very important in planning future holistic care of HIV-infected patients in our institutes as well as in national policy. Results from the study could be used to develop proper long-term management guidelines for people living with HIV (PLHIV) in Thailand targeted at preventable conditions such as metabolic diseases and certain cancers.

Study Type

OBSERVATIONAL

Enrollment

816

Conditions

HIV Infection Healthy

Eligibility

Sex: ALLMin age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: HIV-infected patients group * HIV positive * 30 years of age or older, both male and female * Thai nationality * Written research informed consent HIV-uninfected patients group * HIV un-infected * 30 years of age or older, both male and female * Thai nationality * Written research informed consent Exclusion Criteria: HIV-infected patients group * Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment * Fasting blood sugar \> 126 mg/dl or on the treatment * Proteinuria * Creatinine \> 1.5 mg/dl * Recent hospitalization * Patient who are having mental disease HIV-uninfected patients group * Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment * Fasting blood sugar \> 126 mg/dl or on the treatment * Proteinuria * Creatinine \> 1.5 mg/dl * Recent hospitalization * Patient who are having mental disease

Locations (1)

The Thai Red Cross AIDS Research Centre

Pathum Wan, Bangkok, Thailand

Outcomes

Primary Outcomes

morbidity

development of other diseases

Time frame: 60 months

HIV related illness

development of opportunistic infection such as Non-Hodkin's lymphoma, Kaposi's sarcoma

Time frame: 60 months

Non HIV-related illness

development of Dyslipidemia, Hypertension, DM, CVD , Cancer, osteopenia, osteoporosis, Renal disease, liver disease

Time frame: 60 months

mortality

death

Time frame: 60 months

CVD

development of CVD

Time frame: 60 months

Data from ClinicalTrials.gov

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