The main purpose of this study is to determine whether four weeks treatment with oral doxycycline is as equally effective as three weeks treatment with intravenous ceftriaxone in patients with Lyme neuroborreliosis. The other purpose is to improve laboratory diagnostics of Lyme neuroborreliosis and further define the manifestations and epidemiology of the disease in Finland.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
210
Doxycycline: 100mg tablet two times per day, four weeks
2 g intravenous once a day, three weeks
Helsinki University Hospital
Helsinki, Finland
Turku University Hospital
Turku, Finland
The improvement of the clinical condition during the study.
The clinical condition of participants will be evaluated with visual analogue scale (from 0 to 10, 0=best) by the participants. The VAS scores are collected before the treatment with antibiotics, and 4 months and 12 months after the treatment.
Time frame: 12 months
The clinical condition evaluated by the participants after 12 months from the treatment
The clinical condition is evaluated with VAS by the participants.
Time frame: 12 months
Central spinal fluid (CSF) pleocytosis
The decline in CSF leukocyte count between the patients in doxycycline and ceftriaxone groups
Time frame: 3 weeks
CSF protein concentration
The decline in CSF protein concentration between the patients in doxycycline and ceftriaxone groups.
Time frame: 3 weeks
CSF lactate level
The decline in CSF lactate level between the patients in doxycycline and ceftriaxone groups.
Time frame: 3 weeks
CSF CXCL13 concentration
The decline in CSF CXCL13 concentration wetween the patients in doxycycline and ceftriaxone groups
Time frame: 3 weeks
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