Vitamin D and Critically Ill Patients

Chinese PLA General Hospital234 enrolled

Overview

The higher rate of vitamin D deficiency is spotted among patients being hospitalized or in critical condition. Especially, vitamin D level below normal prolongs hospital stay and increases incidence of adverse prognosis and pushing up mortality of a number of diseases. However, it is remain unclear the relationship between vitamin D levels and critically ill, especially infection or sepsis. In this study, the investigators evaluate the significance of vitamin D for diagnosis and other relevant assessments of ICU cases, including vitamin D's relevance to sepsis, as well as its value in severity and prognosis assessment, high-performance liquid chromatography and tandem mass spectrometry was used to detect the quantification of the total 25(OH)D in serum of critically ill patients. The investigators speculate that measurement of vitamin D could be taken as an indicator for diagnosis and assessment in critically ill patients.

Study Type

OBSERVATIONAL

Enrollment

234

Conditions

Systemic Inflammatory Response Syndrome Sepsis

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male and female aged 18 years old and over; * Entered ICU; * Fulfilled at least two criteria of systemic inflammatory response syndrome * core temperature higher than 38 °C or lower than 36 °C * respiratory rate above 20/min, or PCO2 below 32 mmHg * pulse rate above 90/min, and * white blood cell count greater than 12,000/μl or lower than \< 4,000/μl or less than 10% of bands. Exclusion Criteria: * patients or their relatives refused

Outcomes

Primary Outcomes

Patients Outcome

The survival time of patients more than 28 days is defined as survival. The survival time of patients less than 28 days is defined as death.

Time frame: 28 days