18F-FDG PET/CT and Molecular Tumor Characterisation for Staging and Follow-up of Colon Cancer

Naestved Hospital66 enrolled

Overview

The investigators are investigating the usefulness of 18F-Fluordeoxyglucose Positron Emission Tomography/ Computed Tomography (18F-FDG PET/CT) for staging and follow-up of colon cancer. Furthermore, the investigators combine 18F-FDG PET findings with clinical and histopathological features, circulating tumor cell (CTC) analyses, tumor gene expression and measurements of circulating cancer biomarkers sUPAR, TIMP-1 and CEA in order to predict tumor recurrence. The investigators hypothesis: The combination of functional imaging by 18F-FDG PET/CT and pre-existing and evolving molecular biomarkers will optimize tumor characterization, staging of disease and early detection of recurrence.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Colon Cancer

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * clinical or histological diagnosis of malignant clonic neoplasm (distance of more than 15 cm from anal ring) * 18 years of age or older * written informed consent Exclusion Criteria: * diabetes * known malignant disease other than colon cancer * known metastatic disease * impairment of renal function * allergy to CT contrast agents * body weight of more than 150 kg * claustrophobia

18F-FDG PET/CT and Molecular Tumor Characterisation for Staging and Follow-up of Colon Cancer

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes