Plasma Concentrations of Bupivacaine After Peri-articular Injection in Total Knee Arthroplasty

Mahidol University43 enrolled

Overview

Patients with knee arthroplasty usually performed under spinal anesthesia with a single-shot femoral nerve block and periarticular block, so we would like to know the plasma concentration of bupivacaine in these patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Serum Bupivacaine Level Periarticular Block Total Knee Arthroplasty

Interventions

BupivacaineDRUG

20 ml of 0.5% bupivacaine for single-shot femoral nerve block will be done at the beginning then another 20 ml of 0.5% bupivacaine for periarticular block will be performed at the end of operation. Blood sample will be drawn at 60 min after femoral nerve block and before periarticular block, 15, 30, 45, 60 min after periarticular block.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age of 30-70 yr * ASA I-II * patient undergo total knee arthroplasty under spinal block and single shot femoral nerve block and periarticular block Exclusion Criteria: * patient's refusal * allergic to bupivacaine * body weight less than 50 kg * liver disease * heart disease * coagulopathy * Hct\<35% * infection at both groin

Locations (1)

Faculty of Medicine, Siriraj Hospital, Mahidol University

Bangkok, Bangkok, Thailand

Outcomes

Primary Outcomes

plasma concentration of bupivacaine after spinal anesthesia with single-shot femoral nerve block and periarticular block

Time frame: 2 hours

Secondary Outcomes

bupivacaine toxicity

Time frame: 24 hr

Data from ClinicalTrials.gov

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