Single Rising Oral Doses of BI 1021958 in Healthy Chinese and Japanese Male Volunteers

Inclusion criteria: 1. Healthy males based upon a complete medical history, including a physical examination, vital signs (blood pressure, pulse rate), 12-lead ECG, and clinical laboratory tests 2. Chinese ethnicity, Japanese ethnicity according to the following criteria Japanese; born in Japan, be a current Japanese passport holder, have lived outside of Japan \<5 years, and have parents and grandparents who were all born in Japan Chinese; ethnic Chinese, born in China or ethnic Chinese born outside of China, and a descendent of 4 ethnic Chinese grandparents who were all born in China 3. Age within the range of 20 to 45 years 4. Body mass index within the range of 18.5 and 25 kg/m2 5. Signed and dated written informed consent prior to admission to the study in accordance with GCP and the local legislation. Exclusion criteria: 1. Any finding of the medical examination (including Blood Pressure, Pulse Rate, ECG and Safety laboratory) deviating from normal and of clinical relevance 2. Any evidence of a clinically relevant concomitant disease 3. Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders 4. Surgery of the gastrointestinal tract (except appendectomy) 5. Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders 6. History of relevant orthostatic hypotension, fainting spells or blackouts. 7. Chronic or relevant acute infections 8. History of relevant allergy/hypersensitivity (including allergy/hypersensitivity to the study drug or its excipients) 9. Intake of drugs with a long half-life (more than 24 hours) within at least 1 month or less than 10 half-lives of the respective drug prior to administration 10. Use of drugs which might reasonably influence the results of the trial or that prolong the QT/QTc interval (based on the knowledge at the time of protocol preparation) within 10 days prior to administration 11. Participation in another trial with an investigational drug administration within 2 months prior to administration 12. Smoker (more than 10 cigarettes or 3 cigars or 3 pipes/day) 13. Inability to refrain from smoking on trial days 14. Alcohol abuse (more than 30 g/day) 15. Drug abuse 16. Blood donation (more than 100 mL within 4 weeks prior to administration) 17. Any laboratory value outside the reference range that is of clinical relevance 18. Inability to comply with dietary regimen of trial site 19. A marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTc interval more than 450 ms), heart rate outside 45 to 90 bpm, or any other relevant ECG findings at screening 20. A history of additional risk factors for TdP (e.g., heart failure, hypokalemia, family history of long QT Syndrome) 21. Subjects considered unsuitable for inclusion by the investigator, e.g. because considered not able to understand and comply with study requirements, or have any condition which in the opinion of the investigator would not allow safe participation in the study