The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

Diskapi Teaching and Research Hospital36 enrolled

Overview

The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers. Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Total Knee Arthroplasty Tourniquet-Induced Ischemia-Reperfusion Injury

Interventions

PropofolDRUG

Propofol :Propofol is an anesthetic agent, has structure similar to that of known such as alfa tocopherol.

PlaceboDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I-II physical status * Unilateral total knee arthroplasty * Age 18 years to 80 years Exclusion Criteria: * Severe central nervous system disorders * Severe cardiopulmonary,renal,metabolic, or hepatic disease, * Blood volume deficits, * Coagulopathy, * Allergy to local anesthetics, * Peripheral neuropathies, * Body mass index \> 35, * History of antioxidant drug use

Locations (1)

Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology and Biochemistry Clinics

Ankara, Turkey (Türkiye)

Outcomes

Primary Outcomes

The perioperative alternation of the venous blood total antioxidant capacity levels of the arms

T1 : Before the spinal anesthesia performed T2 : At 30th min of tourniquet inflation T3 : At 2nd hours of tourniquet deflation

Time frame: T1,T2,T3

Data from ClinicalTrials.gov

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