The present study is a randomized, prospective, single-blinded study. Patients presenting for colonoscopy under sedation will be included according to the statistical sample size calculation. Patients will be randomized to either group 1- capnographic monitoring or group 2- oxygenic monitoring during Propofol-based sedation for colonoscopy. Episodes of Hypoxia are documented and compared in both groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
SINGLE
Enrollment
528
Klinikum der J. W. Goethe-Universität
Frankfurt am Main, Germany
Praxisklinik am Staedel
Frankfurt am Main, Germany
Hypoxia (SO2 <90%)
Study objective is to evaluate if a reduction of hypoxic events (SO2 \<90% for ≥ 15 sec) can be obtained with capnographic monitoring as compared to standard monitoring of respiration with pulse-oxymetry in patients receiving colonoscopy under Propofol-based sedation
Severe Hypoxia (SO2 <85%)
Evaluate events of severe hypoxia (SO2 \< 85%) in group 1 (capnographic monitoring) as compared to group 2 (oxymetric monitoring)
Time to hypoxia
Evaluate the time difference between abnormal ventilation shown on capnography machine and hypoxemia.
Hypoxia in relation to sedation
Compare events of hypoxemia and severe hypoxemia during sedation with propofol only as compared to propofol/ketamin combination sedation.
Vegetative Symptoms
Evaluate vegetative events (hypotension, hypertension, bradycardia, tachycardia, tachypnea, bradypnea) in both groups during the two sedation forms
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