The purpose of this study is to compare the effects of neuromuscular exercise and analgesic use on knee joint load, in patients with mild to moderate knee osteoarthritis (OA). It is expected that the two groups will receive equipotent pain relieving effect, despite this, the investigators expect a between group difference in knee joint load, and the exercise group will have a reduction in knee joint load.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
93
The PHARMA group receives instruction, by video and pamphlet, on how to best use acetaminophen and NSAID as pain management for knee OA.
The exercise group receives 1 hour of supervised neuromuscular exercise two times a week for 8 weeks. Supervision is conducted by physiotherapists specially trained in using neuromuscular exercise and its principles.
University of Southern Denmark
Odense, Region Syddanmark, Denmark
Change from baseline in 1st peak RMS (root mean square) Knee Index.
1st peak RMS Knee Index, is combined of the moments of the 3 planes working over the the knee; flexion, adduction and internal rotation moments. Measured with the Vicon system. 1st peak RMS knee moment = √(Kflex. moment2 + Kadd. moment2 + Kint.rot. moment2 )/3
Time frame: Baseline and post intervention (8 weeks)
Change from baseline in 1st peak Knee adduction moment
Time frame: Baseline and post intervention (8 weeks)
Change from baseline in the KOOS (Knee injury and Osteoarthritis Outcome Score) questionnaire
Time frame: Baseline and post intervention (8 weeks)
Change from baseline in Maximum number of one-leg rises from stool test
This test evaluates maximal performance and muscle strength in the lower extremity
Time frame: Baseline and post intervention (8 weeks)
Change from baseline in Maximum number of knee-bendings in 30s test
This test evaluates the ability to perform fast changes between eccentric and concentric muscle force over the knee joint
Time frame: Baseline and post intervention (8 weeks)
Change from baseline in One-leg hop for distance test
The test mimics sporting activities and demands muscle explosivety, balance and functional stability of the knee
Time frame: Baseline and post intervention (8 weeks)
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