Clomifene Citrate Versus Metformin in First-line Treatment of Infertility in Patients With Polycystic Ovary Syndrome and a Resistance to Insulin

Inclusion Criteria: * Women aged from 18 to 35 * Infertility for a period of a year or more or 6 month of irregular menstrual cycle * PCOS under the Rotterdam criteria * Insulin resistance HOMA-IR \> 2.5 * Normal semen analysis values * Normal values of the following blood analysis: FSH, LH, Estradiol, AMH, TSH, Prolactine, Fasting glucose level, hemoglobin A1C, AST, ALT, alkaline phosphatase, SHBG, 17OH progesterone, DHEAS, Androstenedione, total testosterone, LDL, HDL, total cholesterol, Triglycerides, oral glucose tolerance test Exclusion Criteria: * Tubular factor * Normal ovarian reserve * Prior use of CC or Metformin, hypoglycemic agents, glucocorticoids, anti-androgen, weight-loss agent or oral contraceptives in the past 6 months * Neoplasia * BMI \> 35 * Renal, hepatic or cardiac failure * Lactic, acidosis antecedent