Sustained Virological Response (SVR)Rate of Pegasys Plus Ribavirin in Patients With Chronic Hepatitis C

Inclusion Criteria: * 20\~70 years old * Patients have never been treated with traditional interferon plus ribavirin or peginterferon plus ribarivin * Chronic hepatitis C, genotype 1, HCV-RNA \> 0.8x106 IU/ml, achieving RVR (undetectable HCV RNA at week 4) in the SoC treatment * Patient must be able to comply with the assessments during the study * Compensated liver disease (Child-Pugh Grade A clinical classification for patients with cirrhosis: total score ≦ 6) * All fertile males and females receiving ribavirin must be using two forms of effective contraception during treatment with study drugs and 6 months post treatment completion Exclusion Criteria: * History or other evidence of a medical condition associated with chronic liver disease other than HCV (e.g., hemochromatosis, autoimmune hepatitis, metabolic liver disease, alcoholic liver disease, toxin exposures) * History or other evidence of decompensated liver disease * Signs or symptoms of hepatocellular carcinoma * Co-infection with hepatitis A, hepatitis B or human immunodeficiency virus (HIV) * Not adequately controlled thyroid dysfunction, diabetes mellitus (HbA1c \>8.5%) or psychiatric disorders, especially depression. Severe psychiatric disease is defined as treatment with an antidepressant medication or a major tranquilizer at therapeutic doses for major depression or psychosis, respectively, for at least 3 months at any previous time or any history of the following: a suicidal attempt, hospitalization for psychiatric disease, or a period of disability due to a psychiatric disease * History of a severe seizure disorder or current anticonvulsant use * History of immunologically mediated disease, chronic pulmonary disease associated with functional limitation, severe cardiac disease, major organ transplantation or other evidence of severe illness, malignancy, or any other conditions which would make the patient, in the opinion of the investigator, unsuitable for the study * Evidence of severe retinopathy (e.g. CMV retinitis, macula degeneration) or clinically relevant ophthalmological disorder (e.g. due to diabetes mellitus or hypertension) * Women with on-going pregnancy or breast feeding * Male partners of women who are pregnant * Subjects with any of the following laboratory abnormalities * Platelet count \< 90,000/mm3 * Absolute neutrophil count \< 1,500 /mm3 * Hemoglobin \< 12 g/dL (F), 13 g/dL (M) * Creatinine \> ULN * ALT and/or AST \> 10X ULN * Total serum bilirubin \> 1.5 x ULN * Inability or unwillingness to provide written informed consent or abide by the requirements of the study