Determine whether the amount of drug absorbed is different if the tablet is placed under the tongue, placed between the cheek and gum, or swallowed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
25
Sufenta IV (50 mcg/mL) 15 mcg push over 1 minute (IV)
Single Sufentanil NanoTab 15 mcg given sublingually (SL)
Treatment C: Single Sufentanil NanoTab 15 mcg given buccally (BU)
PRA
Lenexa, Kansas, United States
AUC (0 - Inf)
total amount of sufentanil absorbed
Time frame: 24 hours
Cmax
maximum plasma concentration
Time frame: 24 hours
Tmax
time to maximum plasma concentration
Time frame: 24 hours
CST 1/2
time for maximum plasma concentration to decrease by 50%
Time frame: 24 hours
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Single Sufentanil NanoTab 15 mcg swallowed (PO)