The Effect of Eating Frequency on Blood Pressure

Imperial College London

Overview

The primary purpose of this study is to identify the effect of meal frequency on blood pressure (BP) levels of individuals.

Migration studies, observational epidemiology and clinical trial data indicate that causes of adverse BP levels are mainly environmental , including lifestyle under which dietary factors play a role. Therefore, lifestyle modification is part of the current American Heart Association recommendations for prevention and control of adverse BP levels. Although the effects of nutrients and foods on BP have been studied extensively, other dietetic factors such as eating frequency and number of meals in a day have been less thoroughly investigated and warrant further research to explore their possible positive effect on BP.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Blood Pressure

Interventions

dietary interventionOTHER

a low frequency diet (3 meals/day) a high frequency diet (9 meals/day)

Eligibility

Sex: ALLMin age: 35 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Healthy individuals aged 35-70 years with prehypertension (systolic/diastolic BP 120-139/80-89 mm Hg) BMI 20-30 kg/m2 non-smoking non alcoholic drinkers Exclusion Criteria: * Weight change of ≥ 3kg in the preceding 2 months * Current smokers * Substance abuse * Alcohol intake * Pregnancy * Diabetes * Cardiovascular disease * Cancer * Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome * Kidney disease * Liver disease * Pancreatitis * Use of medications including: anti inflammatory drugs or steroids, antihypertensive drugs, cholesterol lowering medication, androgens, phenytoin, erythromycin or thyroid hormones.

Locations (1)

Sir John Michael Center - Hammersmith Hospital

London, United Kingdom

Outcomes

Primary Outcomes

blood pressure

Participants will be asked to wear BP monitor continuously for one week then return it back either by post or bring it themselves to the center.

Time frame: 2 weeks for 24 hours through blood pressure monitor

Secondary Outcomes

Insulin

biomarkers like: Insulin - Glucose- lipid profile- Free fatty acids- C peptides- HS CRP will be measured regularly during study

Time frame: measured twice during each phase (2 phases)

Data from ClinicalTrials.gov

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