MRI Guided High Intensity Focused Ultrasound (HIFU) and ThermoDox for Palliation of Painful Bone Metastases

Inclusion Criteria: * Histological confirmation of breast carcinoma, non-small cell lung cancer, small cell lung cancer, or adenocarcinoma of the prostate * Bone metastases index lesion in the ribs, clavicle, scapula, upper extremities, pelvis, or posterior aspects of the lumbar vertebra L3-L5 or sacral S1-S5. * Patients will have failed at least one prior attempt or will not be eligible for external beam radiation therapy (EBRT) Exclusion Criteria: * Greater than 450 mg/m2 of prior free doxorubicin and/or non-heat activated liposomal doxorubicin * LVEF \< 50% * Significant Cardiac History * Brain Metastases * Contraindication for MR imaging (as incompatible implanted metallic device, weight \>250 lbs etc) or known intolerance or allergy to MRI contrast agents.