BREATHER (PENTA 16) Short-Cycle Therapy (SCT) (5 Days on/2 Days Off) in Young People With Chronic HIV-infection

Inclusion Criteria: * HIV-1 infected young people aged 8 to 24 years inclusive (Young people recruited between the ages of 16-21 must either be in regular physical contact with their clinician or be able to transfer to an adult physician at the same site for follow-up or to an affiliated adult site). * Parents/carers and/or young people, where applicable, willing to provide informed consent. * On a stable first-line ART treatment containing at least 2 NRTIs/NtRTIs and EFV for at least 12 months and willing to continue the regimen throughout the study period. Young people on regimens containing nevirapine (NVP) or a boosted protease inhibitor with undetectable viral load for over one year who wish to enrol should switch to EFV. Once they are stable on the EFV containing regimen for more than 12 weeks they may be enrolled (must have 2 subsequent HIV-1 RNA measurements \<50 c/ml over a minimum period of 12 weeks). Previous dual therapy and/or substitution of NRTIs is allowed providing any changes were not for disease progression, immunological or virological failure (where virological failure is defined as two successive HIV-1 RNA results\>1000 c/ml) subsequent to virological control having been achieved on ART. * Viral suppression (HIV-1 RNA \<50 c/ml) for at least the prior 12 months (at least the last 3 measurements, including screening): young people who have experienced a single viral load \>50 but \<1000 copies/ml (preceded and followed by VL\<50 c/ml) in the last 12 months can be enrolled. * CD4 cell count ≥350 106/L at screening visit. * Centre must routinely use an assay which detects HIV RNA-1 viral load ≥50 c/ml. Exclusion Criteria: * Pregnancy or risk of pregnancy in females of child bearing potential. * Acute illness (young people may be enrolled after illness). * Receiving concomitant therapy for an acute illness (young people may be enrolled after finishing therapy). * A creatinine, AST or ALT of grade 3 or above at screening. * On a regimen including nevirapine or a boosted PI (young people may switch to an EFV based regimen). * Previous ART monotherapy (except for the prevention of mother-to-child transmission)