The study will compare the airway responses to two bronchoconstricting agents, mannitol and methacholine.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
20
two minutes of aerosol inhalation of concentrations of methacholine ranging from 0.03 - 256mg/mL
single deep inhalation of dry powder per dose doses range from 0mg - 160mg (cumulative dose range 0mg-635mg).
two minutes of aerosol inhalation of concentrations of methacholine ranging from 0.03 - 256mg/mL every 20 seconds a deep inhalation is performed
University of Saskatchewan
Saskatoon, Saskatchewan, Canada
Airway responsiveness (PC20) to methacholine delivered over two minutes of tidal breathing
The two minute tidal breathing PC20 with be captured once at visit 1.
Time frame: Visit 1 (Day 1)
airway responsiveness (PD15) to inhaled mannitol
The PD15 to mannitol will be captured once at either visit 2 or visit 3.
Time frame: Visit 2 = up to 13 days
Airway responsiveness (PC20) to deep inhalation methacholine
The PC20 to methacholine (deep inhalation) will be captured once at either visit 2 or visit 3.
Time frame: Visit 3 = up to 14 days
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