Cancer Biology of Retinoblastoma

Stanford University8 enrolled

Overview

Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Retinoblastoma

Eligibility

Sex: ALLMax age: 5 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient must have retinoblastoma * Patient must be receiving biopsy, partial surgical excision of the tumor, complete excision of the tumor, or enucleation of the eye as part of their standard care. * Parental consent Exclusion Criteria: * Diagnosis other than Retinoblastoma * No surgical sampling of tumor is planned as part of standard care * Parental preference to not participate.

Locations (2)

Stanford University Cancer Institute

Stanford, California, United States

Unidad Nacional de Oncologia Pediatrica

Guatemala City, Guatemala

Outcomes

Primary Outcomes

Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations

Comparison of number of reprogramming events (defined by colony formation assay and normalized for number of cell plated) as well as the time to reprogramming.

Time frame: After appropriate time, e.g., 7, 10, 14 days after reprogramming

Data from ClinicalTrials.gov

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