Cytokine Profiling Post-Heart Transplant

N/ATerminatedNCT01643564

University of Minnesota34 enrolled

Overview

Measurement of cytokine levels in post-cardiac transplant patients with unexplained graft dysfunction.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiac Transplant

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Group 1 * 18 years and older * Cardiac Transplant recipient with graft dysfunction of unknown etiology Group 2 * 18 years or older * No history of heart failure or cardiac transplantation Group 3 * 18 years or older * Class II-IV heart failure Group 4 * 18 years or older * Heart Transplant 6 months or greater prior to blood draw * No graft dysfunction Exclusion Criteria: Group 1 Heart Transplant with Unexplained Graft Dysfunction * Cellular or antibody-mediated cardiac allograft dysfunction Group 2 Normal Control group * Active infection within 1 month of blood draw * Known Inflammatory Disease Group 3 Heart Failure Group * Active infection within 1 month of blood draw * Known Inflammatory Disease Group 4 Heart Transplant with Normal Graft Function Group * Active infection within 1 month of blood draw * Known graft dysfunction * Known Inflammatory Disease

Outcomes

Primary Outcomes

Differences in cytokine profiles between stable heart transplant recipients and those with acute rejection

Time frame: 12 months

Data from ClinicalTrials.gov

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