Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Lumbar Intervertebral Disc Degeneration

Inclusion Criteria: * Subjects who understand and sign the consent form for this study * Age :19-70, males and females * Have chronic low back pain for at least 1 year * Have failed 1 year of non-operative low back pain management * Have degenerated intervertebral disc on T2-weighted MR images * confirmed by positive discography * Have significant lumbar instability at degenerated intervertebral disc Exclusion Criteria: * Have significant lumbar herniated intervertebral disc * Women who are pregnant or breast feeding or planning to become pregnant during the study * History or current evidence of alcohol or drug abuse or is a recreational user of illicit drugs or prescription medications * Serious pre-existing medical conditions like Cardiovascular Diseases, Renal Diseases, Liver Diseases, Endocrine Diseases, Cancer and Diabetes Mellitus * Participation in another clinical trial or treatment with a different investigational product within 30 days prior to inclusion in the study * Other pathologic conditions or circumstances that difficult participation in the study according to medical criteria