Safety Study of Chimeric Vaccine to Prevent ETEC Diarrhea

Inclusion Criteria: * Healthy, adult, male or female, age 18 to 45 years (inclusive) at the time of enrollment. * Completion and review of comprehension test (achieved \> 70% accuracy). * Signed informed consent document. * Available for the required follow-up period and scheduled clinic visits. * Women: Negative pregnancy test with understanding (through informed consent process) to not become pregnant during the study or within three (3) months following study completion. Exclusion Criteria: * Health problems (for example, chronic medical conditions such as psychiatric conditions, diabetes mellitus, hypertension or any other conditions that might place the subjects at increased risk of adverse events. Study clinicians, in consultation with the PI, will use clinical judgment on a case-by-case basis to assess safety risks under this criterion. The PI will consult with the Research Monitor as appropriate. * Clinically significant abnormalities on physical examination. * Use of immunosuppressive medications (systemic corticosteroids or chemotherapeutics that may influence antibody development), or immunosuppressive illness, including IgA deficiency (defined by serum IgA below the detectable limit). * Women who are pregnant or planning to become pregnant during the study period plus 3 months beyond the last study safety visit and currently nursing women. * Participation in research involving another investigational product (defined as receipt of investigational product or exposure to invasive investigational device) 30 days before planned date of first vaccination or anytime through the last study safety visit. * Positive blood test for HBsAg, HCV, HIV-1. * Clinically significant abnormalities on basic laboratory screening. * Exclusionary skin history/findings that would confound assessment or prevent appropriate local monitoring of AEs, or possibly increase the risk of an AE. * History of chronic skin disease (clinician judgment). * History of atopy such as active eczema. * Acute skin infection/eruptions on the upper arms including fungal infections, severe acne or active contact dermatitis. * Allergies that may increase the risk of AEs. * Regular use (weekly or more often) of antidiarrheal, anti-constipation, or antacid therapy. * Abnormal stool pattern (fewer than 3 stools per week or more than 3 stools per day) on a regular basis; loose or liquid stools on other than an occasional basis. * Prior exposure to ETEC or Vibrio cholera. * History of microbiologically confirmed ETEC or cholera infection. * Travel to countries where ETEC or V. cholera or other enteric infections are endemic (most of the developing world) within two years prior to dosing clinician judgment). * Received previous experimental ETEC or V. cholera vaccine or live ETEC or V. cholera challenge. * Occupation involving handling of ETEC or V. cholera currently, or in the past 3 years.