Respiratory Variations in the Diameter of the Inferior Vena Cava With Spontaneous Ventilation

Centre Hospitalier Universitaire de Nīmes52 enrolled

Overview

The main objective of this study is to determine a threshold value of diaphragmatic excursion (ultrasound measures: expiration versus inspiration)that best predicts a 50% collapsibility of the inferior vena cava.

Secondary objectives of this study are: * to determine a threshold value of diaphragmatic excursion (ultrasound measures: expiration versus inspiration)that best predicts a 40% collapsibility of the inferior vena cava (IVC). * to determine a threshold value of diaphragmatic excursion (ultrasound measures: expiration versus inspiration)that best predicts a 100% collapsibility of the IVC. * to determine the location of the cutting plane for the TM analysis of collapsibility of the IVC. * to evaluate the hemodynamic conditions of normal healthy volunteers. * to detect any abnormality of cardiac function.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Collapsibility of the Inferior Vena Cava

Interventions

Ultrasounds with controlled breathingPROCEDURE

The patient will have cardiac, abdominal and thoracic ultrasounds with controlled and monitored inspiratory effort. This gesture takes about 40 minutes.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The volunteer must have given his/her informed and signed consent * The volunteer must be insured or beneficiary of a health insurance plan Exclusion Criteria: * The volunteer is participating in another study * The volunteer is in an exclusion period determined by a previous study * The volunteer is under judicial protection, under tutorship or curatorship * The volunteer refuses to sign the consent * It is impossible to correctly inform the volunteer * The patient is pregnant, parturient, or breastfeeding * The volunteer has known heart disease like heart failure, cardiac arrhythmia * The volunteer takes cardiotropics * The volunteer has known lung disease: obstructive or restrictive respiratory failure * The volunteer has clinical signs of COPD (coughing with morning sputum in a smoking subject) * Any emergency situation

Locations (1)

CHU de Nîmes - Hôpital Universitaire Carémeau

Nîmes, France

Outcomes

Primary Outcomes

Collapsibility score for the IVC diameter

percentage = ((max-min)/average)\*100% Three variables are necessary to respond to the primary objective: (the collapsibility score for the IVC diameter; (2) whether or not this score is \>= 50%; and (3) a measure of the diaphragmatic excursion.

Time frame: Baseline (Day 0; cross-sectional study)

Collapsibility score for the IVC diameter >= 50% (presence/absence)

Time frame: Baseline (Day 0; cross-sectional study)

Diaphragmatic excursion

Maximum distance between the position of the diaphragmatic dome during inspiration versus expiration (cm) Three variables are necessary to respond to the primary objective: (the collapsibility score for the IVC diameter; (2) whether or not this score is \>= 50%; and (3) a measure of the diaphragmatic excursion.

Time frame: Baseline (Day 0; cross-sectional study)

Secondary Outcomes

Collapsibility score for the IVC diameter >= 40% (presence/absence)

percentage = ((max-min)/average)\*100%

Time frame: Baseline (Day 0; cross sectional study)

Collapsibility score for the IVC diameter >= 60% (presence/absence)

percentage = ((max-min)/average)\*100%

Time frame: Baseline (Day 0; cross sectional study)

Mitral Doppler Wave E speed

cm/s

Time frame: Baseline (Day 0; cross sectional study)

Data from ClinicalTrials.gov

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