Identification in Obese Patients of the Mechanism Involved in Intramuscular Lipid Accumulation

University Hospital, Montpellier33 enrolled

Overview

The study aims to determine in obese patients the implication of intramuscular lipid accumulation in relation with insulin resistance and defect in lipid oxidation.

Obese insulin sensitive and obese insulin resistant patients undergo a glucose tolerance test, indirect calorimetry during exercise and muscular biopsy.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

NONE

Enrollment

Conditions

Obesity Insulin Resistance Hyperlipidemia

Interventions

Lipid accumulation analysisOTHER

The lipid accumulation will be assessed with muscular biopsies.

Eligibility

Sex: MALEMin age: 40 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Obese patients with a Body Mass Index (BMI) between 30 and 40 kg/m2 * Patients who do not practice physical exercise (Voorips index \< 9) * Age between 40 and 70 years- Male gender * Fast blood glucose \<1,10 g/l and no hypoglycemic treatment * Signed informed consent * Social security affiliation * Absence of anti VIH, anti hepatitis C antibodies, and HBS antigen * Normal biological tests * Non smoking persons Exclusion Criteria: * Patients who refuse the anti-VIH, anti-hepatitis C antibodies, and HBS antigens tests * Patients treated by anticoagulant, b blockers, lipopenic, or anti-inflammatory. * Patients with a contraindication to muscular exercise (retinopathy, coronaropathy, nephropathy) and to muscular biopsy * Allergy to local anaesthetic

Locations (1)

CHRU Montpellier

Montpellier, France

Outcomes

Primary Outcomes

lipid accumulation in skeletal muscle

Time frame: 1 month

Secondary Outcomes

lipid accumulation in myotubes from obese patients

Time frame: 1 month

Data from ClinicalTrials.gov

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