Prospective Study on Plasma Pro-endothelin-1 in Predicting Bronchopulmonary Dysplasia

University of Zurich110 enrolled

Overview

Serial quantitative measurements of plasma pro-endothelin-1 concentrations in very preterm infants. Comparing pro-endothelin-1 with established clinical indices of bronchopulmonary dysplasia (BPD). Hypothesis: Pulmonary-vascular remodeling in infants developing BPD is directly related to circulating pro-endothelin-1, which therefore serves as surrogate marker of BPD.

Study Type

OBSERVATIONAL

Enrollment

110

Conditions

Bronchopulmonary Dysplasia

Interventions

blood samplingOTHER

blood sampling

Eligibility

Sex: ALLMin age: 2 WeeksMax age: 4 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * Very preterm infants born before 32 weeks gestational age Exclusion criteria: * Severe fetal malformation, congenital heart defect, inborn syndrome, cardiomyopathy, fetal hydrops

Locations (1)

University Hospital Zurich, Division of Neonatology

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

duration of supplemental oxygen requirement

Bronchopulmonary dysplasia

Time frame: 36 weeks postmenstrual age

Secondary Outcomes

duration of respiratory pressure support

respiratory pressure support either mechanical and/or nCPAP (days)

Time frame: during hospitalisation

Data from ClinicalTrials.gov

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