This is an interventional study on Duchenne muscular dystrophy patients who will be receiving sedation for a muscle biopsy as part of another study.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
53
1 mg/kg IV, additional doses of 0.5 mg/kg as needed
0.5 mcg/kg/hr IV
Nationwide Children's Hospital
Columbus, Ohio, United States
Time to Sedation Score of 3-4
The depth of sedation was judged using the University of Michigan Sedation Scale (UMSS). The score ranges from zero, awake and alert, to four, unarousable. A score of three, deeply sedated, or more was considered to be an appropriate level of sedation for the procedure.
Time frame: Immediately prior to incision
Heart Rate Change After Dexmedetomidine Loading Dose
Difference in heart rate from baseline to immediately following infusion of dexmedetomidine loading dose.
Time frame: Baseline to immediately post dexmedetomidine infusion.
Mean Arterial Pressure (MAP) Change After Dexmedetomidine Loading Dose
Change in MAP from baseline measurement to immediately post dexmedetomidine infusion measured via blood pressure cuff.
Time frame: Baseline to immediately post dexmedetomidine infusion.
Oxygen Saturation Change After Dexmedetomidine Loading Dose
Change in oxygen saturation from baseline measurement to immediately post dexmedetomidine infusion.
Time frame: Baseline to immediately post dexmedetomidine infusion.
EtCO2 Change After Dexmedetomidine Loading Dose
Change in end-tidal carbon dioxide from baseline measurement to immediately post dexmedetomidine infusion.
Time frame: Baseline to immediately post dexmedetomidine infusion.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.