Effects of Lysozyme on Acute Exacerbation of Chronic Obstructive Pulmonary Disease : A Randomised Placebo-Controlled Study

Inclusion criteria; * Patients were eligible for inclusion in the study if they were over 20 years of age and below 85 years of age, and had a smoking history, a diagnosis of COPD, a ratio of FEV1 to forced vital capacity(FVC) of less than 70%, and a documented history of at least one exacerbation leading to any treatment within the previous year. Exclusion criteria; * Patients with egg allergy * Patients with domiciliary oxygen therapy * Patients with pneumonia or pulmonary tuberculosis * Patients with severe cardiovascular disorder,severe kidney disorder, severe hepatic disorder, severe hematological disorder. * Patients with cancer.