Efficacy and Safety of Tripterygium Wilfordii in Patients With Lupus Nephritis

Inclusion Criteria: * Age 18-65 years with informed consent * SLE defined by meeting 4 or more ACR classification criteria * Biopsy-proven active proliferative lupus glomerulonephritis ISN classification Class III or IV * Active renal disease Exclusion Criteria: * Pregnant, lactating or further fertility requirements * Serum creatinine \> 3 mg/dL * Serum ALT or AST \> 3 times upper limit of normal * Severe, progressive renal, hepatic, hematological, gastrointestinal, pulmonary, cardiovascular, neurological, endocrine or cerebral disease * Previous treated with cyclophosphamide or T2. * Not discontinuing MMF, azathioprine, leflunomide, methotrexate, calcineurin inhibitor before 1 month of randomization. * Active or chronic infection, including HIV, HCV, HBV, tuberculosis * Patient with malignancy