Comparison of Nikkomycin Z Bioavailability Under Fed and Fasting Conditions

Inclusion Criteria: * Be at least 18 years of age and not over 40 years of age * Be male, or female (non childbearing potential or using adequate contraception) * Have a body mass index between 18 and 29 kg/m2 * Able to understand the study and give written informed consent * Be determined healthy based on a medical and laboratory evaluation Exclusion Criteria: * Patients under the age of 18 years or over 40 years of age * Current smoker or history of smoking within 3 months of participation * Inability to comprehend study and provide written informed consent * Inability to comply with the study requirements * History of or current evidence of major organ disease * Renal disease - serum creatinine \> 1.5 mg/dL, significant hematuria or proteinuria, known structural abnormality or chronic kidney disease * Hepatic disease - active viral hepatitis, history of hepatitis B or hepatitis C, bilirubin \> 2.0, ALT or AST above normal upper limit for laboratory, alcoholic liver disease, other chronic liver disease * CNS disease or cognitive dysfunction - any past history of epilepsy, CNS infections, stroke, CNS bleed, severe headaches, major psychiatric illness, or current mental status changes * Lung disease - history of severe asthma, COPD, pulmonary tuberculosis, or other major lung disease * Cardiac disease - history or current evidence of ischemic coronary artery disease, myocardial infarction, heart failure, or significant arrhythmia * Gastrointestinal disease - presence of inflammatory bowel disease, difficulty swallowing, or any gastrointestinal probably that would limit taking oral medications or that may compromise absorption of oral medications * Cancer - History of hematologic malignancy or solid tumor excluding basal cell carcinoma limited to the skin within the past 5 years * History of autoimmune or inflammatory disease such as rheumatoid arthritis and lupus * Immunocompromised state - solid organ transplant, cancer chemotherapy, stem cell transplant with graft versus host disease, immunosuppressive therapy, or HIV infection * Recent weight loss of greater than 10% * Any other history or evidence of disease that in the opinion of the physician would increase the risk for the subject for clinical trial participation * Regular use of prescription medications, over-the-counter medications, or dietary/herbal supplements within 14 days of day 1. Occasional use of acetaminophen or over-the-counter NSAID within the 14 day window may be allowed at the P.I. discretion * Subjects who received another investigational drug within 30 days of enrollment