Dydrogesterone is a retroprogesterone with a molecular structure similar to natural progesterone. As a C-21 steroid, it has a high affinity for progesterone receptors, a low antigonadotropic activity and antiestrogenic activity, but almost no estrogenic or androgenic activity. Dydrogesterone (Duphaston©) is indicated for dysfunctional bleeding. In this study, women suffering from menorrhagia and who are treated with dydrogesterone will be observed for impact on QoL with the reduction in severity of bleeding.
Study Type
OBSERVATIONAL
Enrollment
210
Site reference ID/Investigator# 79836
Islamabad, Federal Capital, Pakistan
Site Reference ID/Investigator# 77674
Karachi, Sindh, Pakistan
Site Reference ID/Investigator# 77675
Karachi, Sindh, Pakistan
Site reference ID/Investigator# 77676
Karachi, Sindh, Pakistan
Site Reference ID/Investigator# 77677
Karachi, Sindh, Pakistan
Site Reference ID/Investigator# 77680
Karachi, Sindh, Pakistan
Site Reference ID/Investigator# 77681
Karachi, Sindh, Pakistan
Site reference ID/Investigator # 77690
Lahore, Punjab, Pakistan
Site Reference ID/Investigator# 77691
Lahore, Punjab, Pakistan
Site reference ID/Investigator# 77694
Lahore, Punjab, Pakistan
...and 10 more locations
EQ-5D Quality of Life questionnaire
The EQ-5D assesses five dimensions of HRQOL: mobility, self-care, usual activities, pain or discomfort, and anxiety or depression. Each dimension is measured on a three-point ordinal scale where a higher score corresponds to a worse health state (no limitation, some limitation, and greatest limitation in HRQOL). This will be evaluated at baseline and then at each follow up visit to see impact on quality of life.
Time frame: 3 months
Pictorial Blood Assessment Chart (PBAC) score
PBAC score of 100 or more corresponds with heavy menstrual bleeding. PBAC score will be assessed at each visit to see any improvement.
Time frame: 3 months
Menstrual Cycle Diary
Change in the nature of menstruation will be taken into account based on the subjects' perception as recorded on the Menstrual Cycle Diary.
Time frame: 3 months
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