Screening for Preeclampsia With Various Markers in Low-risk Pregnancy Populations

CHA University262 enrolled

Overview

For the prediction of late-onset preeclampsia (PE) in low risk women, the investigators established a cut-off value for sFlt-1/PlGF ratio and evaluated the combination models of Elecys, second trimester uterine artery (UtA) doppler, and fetoplacental proteins for Down syndrome screening.

A prospective study was carried on in Cha hospital. Serum samples for Down syndrome screening were assayed to estimate pregnancy-associated plasma protein-A (PAPP-A), alpha-fetoprotein , unconjugated estriol, human chorionic gonadotrophin , and inhibin-A. Women screened for Down syndrome were offered UtA Doppler at 20-24 weeks of gestation and then collected serial serum samples for sFlt-1/PlGF ratio at two time points (24-27 and 34-37 weeks' gestation).

Study Type

OBSERVATIONAL

Enrollment

262

Conditions

Preeclampsia

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 39 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women considered as a potential participant in this research were patients regularly visited at the prenatal care of Cha hospital in Seoul, Korea Exclusion Criteria: * early onset and cases not to measure the sFlt/PlGF ratio and other markers * twin pregnancy * Chronic hypertension * prior history of preeclampsia * pregestational diabetes mellitus * gestational diabetes mellitus * patients delivered before 35 weeks of gestation * preeclamptic patients with onset before 35 weeks of gestation * patients with body mass index 25kg/m2 or greater * maternal age 40 years older

Outcomes

Primary Outcomes

identification of patients at risk for late-onset preeclampsia with sFlt-1/PlGF ratio

Time frame: at delivery

Secondary Outcomes

identification of patients at risk for late-onset preeclampsia with combined biochemical markers

Time frame: at delivery

Data from ClinicalTrials.gov

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