Sleep, Cognition and Memory Disorder

University Hospital, Bordeaux58 enrolled

Overview

The increasing incidence of Alzheimer's disease (AD) and related sleep-disorders with the aging of the population is a major issue of public health. The prevalence of sleep disturbances is about 50% in dementia patients. Sleep in dementia is mainly characterized by prolonged night-time awakenings, sometimes with longer sleep latency and/or early awakening. The presence of these sleep disturbances is the main reason for the institutionalization of AD patients, as well as a major cause of the deterioration of the caregivers' sleep. The MEMENTO cohort is composed of patients with isolated memory complaints or mild cognitive impairment, at high risk to develop dementia. All voluntary patients from the CMRR (Center of Memory, resources and Research) of Bordeaux (MEMENTO cohort) will be tested at inclusion and followed-up 1 year later. For these two evaluations, actigraphic monitoring at home, 2-night polysomnography (PSG) monitoring at hospital including a 24-hour period of urinary melatonin dosage, neuropsychological tests battery, a virtual reality tool and questionnaires will be used.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Sleep Architecture Sleep Disorders Cognitive Impairment

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria for patients with mild cognitive impairment included in MEMENTO cohort: * Aged 18 years and above * included in MEMENTO cohort within the last 3 months * Clinical dementia rating scale ≤ 0,5 (not demented) * Patients with mild cognitive impairment * Visual and auditory acuity adequate for neuropsychological testing * Having signed an informed consent * Being affiliated to health insurance Inclusion criteria for patients with mild cognitive impairment not included in MEMENTO cohort: * Aged 18 years and above * First contact with Memory clinic within the last 3 months * Clinical dementia rating scale ≤ 0,5 (not demented) * Patients with mild cognitive impairment * Visual and auditory acuity adequate for neuropsychological testing * Having signed an informed consent * Being affiliated to health insurance Inclusion criteria for Healthy volunteers and Control group: * Aged 18 years and above * Without evidence of psychopathology * Volunteers matched in age, sex and educational level with patients * Visual and auditory acuity adequate for neuropsychological testing * Having signed an informed consent * Being affiliated to health insurance Exclusion criteria: * Being under guardian conservator * Residence in skilled nursing facility * Pregnant or breast feeding woman * Alzheimer's disease caused by gene mutations * Having a neurological disease * History of stroke within the past three months * Generalized anxiety (DSM-IV criteria) * Schizophrenia history (DSM-IV criteria) * Illiteracy, is unable to count or to read