The purpose of this study is to assess the effects of palonosetron on corrected QT interval duration during and after general anesthesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
100
0.075 mg IV as bolus before induction of general anesthesia
2 ml normal saline as bolus before induction of general anesthesia
Seoul National University Hospital
Seoul, South Korea
corrected QT interval (QTc interval)
at 2, 10, 15, 30, 60, 90 minutes after induction of general anesthesia, up to 1 minute after tracheal intubation
Time frame: up to 90 minutes after induction of general anesthesia
proportion of patients whose corrected QT interval (QTc interval) is more than 450 ms for male or 470 ms for female
Time frame: up to 2 hours after induction of general anesthesia
corrected QT interval (QTc interval) at Postanesthetic care unit
Time frame: up to 1 hour after arrival on postanesthetic care unit
Incidence of postoperative nausea and vomiting
Time frame: for 24 hours after surgery
proportion of patients who have more than 500 ms of corrected QT interval (QTc interval)
Time frame: up to 2 hours after induction of general anesthesia
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