Copperhead Envenomation Observational Study

Inclusion Criteria: * Envenomation by a copperhead snake * Presentation for care at a health care facility within 24 hrs of envenomation * Envenomation on an extremity distal to the knee or elbow * Clinical evidence of venom effect (limb swelling and/or tenderness) * Enrollment can be completed within 48 hrs of envenomation prior to discharge * Patient is willing and able to complete follow-up schedule of assessments * Patient is able to read, comprehend and sign IRB approved informed consent * Patient is able to read and comprehend written assessment tools * Patient is at least 18 yrs old * Patient is sober, competent and able to complete verbal and written informed consent Exclusion Criteria: * Patient is pregnant or breastfeeding * Patient is a prisoner * Patient has distracting injury, condition with acute pain or functional impairment, and/or is unable to make a reliable self-report of status * Patient has had previous snake envenomation to any body area within 30 days prior to screening/enrollment, regardless of whether antivenom was administered * Patient had an acute traumatic or medical event, surgery, or exacerbation of pre-existing medical or surgical condition effecting the envenomated extremity within 30 days prior to screening/enrollment * Patient has participated in a clinical study involving and investigational pharmaceutical product or device within 3 months prior to screening that may have impact on clinical outcomes of snakebite * Patient has previously participated in this study * Patient is, in the investigator's opinion, otherwise unsuitable for participation. Note: Treatment with antivenom prior to eligibility evaluation is not an exclusion criterion