A Study to Assess the Systemic Pharmacokinetics, Metabolism and Excretion Routes of YM178 in Man, After Administration of Radio-labeled YM178

Inclusion Criteria: * Body weight between 60 and 100 kg, and BMI ≤30 kg/m2 Exclusion Criteria: * Known or suspected hypersensitivity to β-adrenergic receptor agonists or constituents of the formulations used * Any clinically significant history of asthma, eczema, any other allergic condition or previous severe hypersensitivity to any drug * Any clinically significant history of upper gastrointestinal symptoms (such as nausea, vomiting, abdominal discomfort or upset, or heartburn) in the 4 weeks prior to admission to the Research Unit * Any clinically significant history of any other disease or disorder - gastrointestinal, cardiovascular, respiratory, renal, hepatic, neurological, dermatological, psychiatric or metabolic * Abnormal pulse rate measurement (\<40 or \>90 bpm) taken by manual counting at the pre-study visit after subject has been resting in supine position for 5 min * Abnormal blood pressure measurements taken at the pre-study visit after subject has been resting in supine position for 5 min as follows: * Systolic blood pressure \<95 or \>160 mmHg; * Diastolic blood pressure \<40 or \>95 mmHg. * Positive orthostatic test at screening i.e. any symptoms of dizziness, light-headedness etc. and/or a fall of ≥ 20 mmHg in systolic blood pressure after 2 min standing (preceded by 5 min. supine rest) and/or an increase in pulse rate of ≥ 20 bpm * Regular use of any prescribed or OTC (over the counter) drugs except paracetamol up to 3 g/day, in the 4 weeks prior to admission to the Research Unit OR any use of such drugs in the 2 weeks prior to admission to the Research Unit * History of drug abuse at any time, OR any use of drugs of abuse within 3 months prior to admission to the Research Unit * History of smoking more than 10 cigarettes (or equivalent amount of tobacco) per day within 3 months prior to admission to the Research Unit * History of drinking more than 21 units of alcohol per week (1 unit = 270 cc of beer or 40 cc of spirits or 1 glass of wine) within 3 months prior to admission to the Research Unit * Donation of blood or blood products within 3 months prior to admission to the Research Unit * Positive serology test for HBsAg, HAV IgM, anti-HCV or anti-HIV 1+2. * Participation in any clinical study within 3 months, or participation in more than 3 clinical studies within 12 months, prior to the expected date of enrolment into the study * Subjects having received YM178 previously * Exposure to radiation for diagnostic reasons (except dental X-rays and plain X-rays of thorax and bony skeleton (excluding spinal column)), during work or during participation in a clinical trial in the previous year