Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation

Yonsei University99 enrolled

Overview

Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .

outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

One Lung Ventilation

Interventions

PEEPOTHER

8 cmH2O PEEP throughout the period of OLV and 2nd TLV

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I-II * age: 20-75 years Exclusion Criteria: * moderate to severe impaired respiratory function, * heart failure, * patients' refusal

Locations (1)

Yong Seon Choi

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

PaO2, number of patients with hypoxia (PaO2< 90mmHg)

blood samplings after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV

Time frame: participants will be followed for the duration of anesthesia, an expected average of 3 hours

Secondary Outcomes

intrapulmonary shunt

blood sampling after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV

Time frame: participants will be followed for the duration of anesthesia, an expected average of 3 hours

Data from ClinicalTrials.gov

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