Methylation Level of SHOX2 in Endobronchial Ultrasound With Real-time Guided Transbronchial Needle Aspiration for Lung Cancer Staging

University Hospital, Essen200 enrolled

Overview

A DNA hypermethylation of the gene locus SHOX2 can be frequently found in lung cancer tissue. The purpose of this study is to determine whether the assessment of the hypermethylation level of SHOX2 in specimens obtained by endosonographic guided bronchoscopy makes a contribution to lung cancer staging.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Lung Cancer With Mediastinal Lymph Node Involvement

Interventions

No interventionOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * clinical diagnosis of lung cancer * enlarged mediastinal or hilar lymph nodes (\>10 mm) Exclusion Criteria: * clinical condition which excludes general anesthesia

Locations (1)

Ruhrlandklinik - Universitätsklinikum Essen

Essen, Germany

Outcomes

Primary Outcomes

Diagnostic Performance of SHOX2

Diagnostic performance of SHOX2 methylation Level as biomarker for lung cancer compared to histologic evaluation of EBUS-TBNA specimen alone.

Time frame: one Year

Data from ClinicalTrials.gov

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